THE POTENTIAL MECHANISM OF CHEBULAE FRUCTUS IN THE TREATMENT OF HEPATOCELLULAR CARCINOMA ON THE BASIS OF NETWORK PHARMACOLOGY

The potential mechanism of Chebulae Fructus in the treatment of hepatocellular carcinoma on the basis of network pharmacology

Introduction and objectives: Hepatocellular carcinoma (HCC) ranks third on the list of the leading cause for cancer death globally.The treatment of HCC patients is unsatisfactory.However, the traditional Chinese medicine Chebulae Fructus has potential efficacy in the treatment of HCC.Materials and methods: We mined the active ingredients of Chebula

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Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells

Urea cycle disorders are incurable enzymopathies read more that affect nitrogen metabolism and typically lead to hyperammonemia.Arginase deficiency results from a mutation in Arg1, the enzyme regulating the final step of ureagenesis and typically results in developmental disabilities, seizures, spastic diplegia, and sometimes death.Current medical

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Comparative Study of Pain-Related Responses of Male Piglets up to Seven Days of Age to the Application of Different Local Anaesthetics and Subsequent Castration

To evaluate pain responses to intratesticular and subscrotal injection of three local anaesthetics and their efficacy during castration a randomized controlled study was conducted.In groups of 20 piglets, procaine (2%), lidocaine (2%), or mepivacaine (2%) were administered subscrotal and intratesticularly in two different dosages: 0.5 mL of the ori

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